The Human Cellular Neurophysiology Laboratory is studying patterns of brain neuronal activity in patients with movement disorders, i.e., Parkinson's disease and dystonia.

Patients are undergoing neurosurgical procedure for implanting deep brain stimulation (DBS) electrodes in the basal ganglia nuclei. These operations not only significantly alleviate the clinical symptoms of movement disorders, but also provide unique opportunity to record the neural activity of the subcortical nuclei in the human brain.
Analysis of neural data helps to clarify fundamental questions concerning the organization of motor control in the basal ganglia system, as well as to lay the foundations for an individualized approaches in adjusting the stimulation parameters for DBS in the subcortical nuclei, on which the clinical effectiveness of neurosurgical intervention ultimately depends.
Лаборатория клеточной нейрофизиологии человека изучает особенности активности нейронов мозга у пациентов с двигательными расстройствами – болезнь Паркинсона и дистония.
Пациентам имплантируют хронические стимулирующие электроды в ядра базальных ганглиев. Такие операции позволяют не только значительно облегчить клинические симптомы двигательных расстройств, но и получить уникальные записи нейронной активности подкорковых ядер головного мозга человека.
research areas
The role of subcortical structures of the human brain in the organization of motor control
Neural mechanisms of motor signal transmission in the basal ganglia in patients with different phenotypes of motor disorders
Pathophysiological mechanisms of Parkinson's disease, dystonia and other motor disorders
Патофизиологические механизмы болезни Паркинсона, дистонии
и других двигательных нарушений
Development of methods to increase the effectiveness of deep brain structures (DBS) stimulation in motor disorders
Search for electrophysiological biomarkers associated with impaired motor control in patients with motor disorders
The role of rhythmic neural processes in normal and pathological human motor activity
Microelectrode registration of human brain single untis during routine stereotactic neurosurgeries aimed to implant electrodes for deep brain stimulation (DBS). The operations are performed under local anesthesia. During the study patients are assigned with a set of functional tests. Simultaneously with microelectrode registration, EMG signals from different muscles and phonogram of verbal commands are also recorded.
Postoperative multichannel recordings of local field potentials (LFP) of subcortical brain structures in patients with motor disorders with simultaneous recording of EEG and EMG signals and phonogram of verbal commands assigning various functional tests.
To contact us,
please, send an email
Address: Moscow, Novatorov street, 7А/1
© Laboratory of Human Cell Neurophysiology , 2023
Novatorov street, 7А/1